ROCK 通道抑制剂-人多能干细胞培养试剂-细胞试剂-中盛溯源
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ROCK 通道抑制剂


Nuwacell™Blebbistatin是广泛应用的非肌肉肌球蛋白II型ATP酶抑制剂。Blebbistatin作用于ROCK-myosinII信号通路,可以阻止多功能干细胞因分离导致的凋亡,在不影响hPSC的自我更新或者多潜能特性的前提下改善分离的hPSC的存活率和克隆效率。



Blebbistatin传代hPSC细胞图片


终浓度2.5μM的Blebbistatin传代hiPSC(P18)形态图片,使用Nuwacell™ hiPSC/hESC 培养基-ncEpic培养。
图示分别为培养第1、2、3天时,显微镜下hiPSC形态图示。标尺:200μm。


文献引用


2020.08-Stem Cell Research(4.495)-Establishment of an induced pluripotent stem cell line from a patient with hereditary transthyretin amyloidosis carrying transthyretin (TTR) mutation p.Phe53Val

He Shan, et al. Stem Cell Research. 2020 Aug 3;48:101940.


2020.10-Stem Cell Research(4.495)-Generation of induced pluripotent stem cell PLAFMCi002-A derived from peripheral blood mononuclear cells of polycystic kidney disease patient with PKD1 mutation

Tao Wang , et al.  Stem Cell Research 49(2020).


2021.01-Ann Transl Med(3.297)-Transplantation of GMP-grade human iPSC-derived retinal pigment epithelial cells in rodent model- the first pre-clinical study for safety and efficacy in China.

Hang Zhang,et al.Ann Transl Med 2021.